| Identification | Back Directory | [Name]
2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | [CAS]
642008-81-9 | [Synonyms]
BRD6989
BRD6989
(BRD-6989
BRD6989 >=98% (HPLC)
2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | [Molecular Formula]
C16H16N4 | [MDL Number]
MFCD04013193 | [MOL File]
642008-81-9.mol | [Molecular Weight]
264.33 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [color ]
white to beige | [InChI]
1S/C16H16N4/c1-10-4-5-14-12(7-10)15(11-3-2-6-19-9-11)13(8-17)16(18)20-14/h2-3,6,9-10H,4-5,7H2,1H3,(H2,18,20) | [InChIKey]
QSYBDNXNOJIKML-UHFFFAOYSA-N | [SMILES]
NC1=NC(CCC(C)C2)=C2C(C3=CN=CC=C3)=C1C#N |
| Hazard Information | Back Directory | [Uses]
BRD 6989, is a small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells. | [Definition]
ChEBI: 2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile is a member of bipyridines. | [Biological Activity]
BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) th at upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ∼200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ∼500 nM and >30 μMrespectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ∼1 μM. | [IC 50]
CDK8: ~200 nM (IC50); recombinant CDK8: ~0.5 μM (IC50); recombinant CDK19: >30 μM (IC50); IL-10 | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|