| Identification | Back Directory | [Name]
1,3-Propanedione, 1-(1,3-benzodioxol-5-yl)-3-(4-methoxy-5-benzofuranyl)- | [CAS]
64280-22-4 | [Synonyms]
1,3-Propanedione, 1-(1,3-benzodioxol-5-yl)-3-(4-methoxy-5-benzofuranyl)- | [Molecular Formula]
C19H14O6 | [MOL File]
64280-22-4.mol | [Molecular Weight]
338.31 |
| Hazard Information | Back Directory | [Uses]
Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42)[1][2]. | [Definition]
ChEBI: Ovalitenone is a member of dihydrochalcones. | [References]
[1] Kittipong Sanookpan, et al. Ovalitenone Inhibits the Migration of Lung Cancer Cells via the Suppression of AKT/mTOR and Epithelial-to-Mesenchymal Transition. Molecules. 2021, 26, 638.
[2] Seru Ganapaty, et al. Flavonoids from Millettia peguensis Ali (Fabaceae). Biochemical Systematics and Ecology 26 (1998) 125-126. |
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