| Identification | Back Directory | [Name]
chinoin 123 | [CAS]
64405-40-9 | [Synonyms]
chinoin 123
4H-Pyrido[1,2-a]pyrimidine-9-acetic acid, 3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-6-methyl-4-oxo-
2-(3-(Ethoxycarbonyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl)acetic acid | [Molecular Formula]
C14H18N2O5 | [MOL File]
64405-40-9.mol | [Molecular Weight]
294.3 |
| Chemical Properties | Back Directory | [Melting point ]
154-155 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
472.0±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [pka]
4.45±0.10(Predicted) |
| Hazard Information | Back Directory | [Originator]
Acitemate ,Onbio Inc. | [Manufacturing Process]
23.6 g of 3-ethoxycarbonyl-7-methyl-4-oxo-6,7,8,9-tetrahydro-4Hpyrido[
1,2a]pyrimidine and 10.0 g of glyoxylic acid monohydrate are reacted
and the obtained 3-ethoxycarbonyl-7-methyl-9-carboxy(hydroxymethyl)-4-
oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2a]pyrimidine is heated in 150 ml ethanol
under stirring for 3 h. After cooling the crystals are filtered off and
recrystallized from ethanol. Thus 3-ethoxycarbonyl-7-methyl-9-
(carboxymethylene)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2a]pyrimidine
melting point 110°-112°C, is obtained (yield: 51%).
55.6 g of 3-ethoxycarbonyl-9-(carboxymethylene)-4-oxo-6,7,8,9-tetrahydro-
4H-pyrido[1,2a]pyrimidine are hydrogenated in 500 ml of ethanol in the
presence of 20.0 g of 9% by weight Pd/C catalyst containing metal. When 1
mole of hydrogen has been used up, the catalyst is removed from the reaction
mixture by filtration and the solution is evaporated under reduced pressure.
The 3-ethoxycarbonyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-9-
acetic acid is obtained (yield: 57%), melting point 156°-157°C (recrystallized
from ethanol). | [Therapeutic Function]
Platelet aggregation inhibitor, Antihyperlipidemic |
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