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Methotrexate-gamma-aspartate is used in antibody targeted liposomes. It also exhibits growth inhibitory effects. | [Uses]
Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate can be used in antibody-targeted liposomes and is promising for research of leukemic[1]. | [References]
[1] Sirotnak FM, et al. Growth inhibitory, transport and biochemical properties of the gamma-glutamyl and gamma-aspartyl peptides of methotrexate in L1210 leukemia cells in vitro. Biochem Pharmacol. 1978;27(14):1821-5. DOI:10.1016/0006-2952(78)90025-4 |
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