| Identification | Back Directory | [Name]
1-METHYLHISTAMINE DIHYDROCHLORIDE | [CAS]
6481-48-7 | [Synonyms]
TIMTEC-BB SBB003561
1-Methylhistamine2HCl
TELE-METHYLHISTAMINE, HCL
1-MethylhistaMine ditosylate
1-METHYLHISTAMINE DIHYDROCHLORIDE
1-Methylhistamine (hydrochloride)
Tele-methylhistamine dihydrochloride
1-METHYL-4-[BETA-AMINOETHYL]IMIDAZOLE
Tele-methylhistamine dihydrochloride salt
1-methyl-4-(β-aminoethyl)imidazole dihydrochloride
1-METHYL-4-[BETA-AMINOETHYL]IMIDAZOLE DIHYDROCHLORIDE
2-(1-Methyl-1H-iMidazol-4-yl)ethanaMine dihydrochloride
1-METHYLHISTAMINE DIHYDROCHLORIDE METABO LITE THAT CROSS
2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine dihydrochloride | [Molecular Formula]
C6H13Cl2N3 | [MDL Number]
MFCD00037000 | [MOL File]
6481-48-7.mol | [Molecular Weight]
198.09 |
| Chemical Properties | Back Directory | [Melting point ]
>198°C (dec.) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
powder
| [color ]
Pale Yellow | [Water Solubility ]
water: 49.00-51.00mg/mL, clear, colorless to faintly yellow | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H | [InChIKey]
AGXVEALMQHTMSW-UHFFFAOYSA-N | [SMILES]
NCCC1N=CN(C)C=1.[H]Cl.[H]Cl |
| Hazard Information | Back Directory | [Description]
1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer’s disease patients as well as those with hypersomnia and other neurological conditions. | [Uses]
1-Methylhistamine Dihydrochloride is a selective H1-receptor agonists. Also it has depressant effects. | [Biochem/physiol Actions]
Major metabolite of histamine by histamine N-methyltransferase. | [IC 50]
Human Endogenous Metabolite | [References]
[1] S.-E. LINDELL R. W S. METABOLISM OF INJECTED [14C]HISTAMINE IN THE KIDNEY OF THE DOG[J]. British Journal of Pharmacology, 1958, 13 1: 52-53. DOI: 10.1111/j.1476-5381.1958.tb00189.x
[2] MOUHAMMAD MOTAWAJ. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease.[J]. Journal of Alzheimer’s disease?: JAD, 2010: 861-871. DOI: 10.3233/jad-2010-100381
[3] YVES DAUVILLIERS. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions.[J]. Sleep, 2012, 35 10: 1359-1366. DOI: 10.5665/sleep.2114 |
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