| Identification | Back Directory | [Name]
RUBUSOSIDE | [CAS]
64849-39-4 | [Synonyms]
Burnside
RUBUSOSIDE
Rubusoside(P)
Rubusoside, >98%
RUBESCENSIN A(RG)
Rubusoside Standard
Rubusoside (100 mg)
Rubus Suavissmus S. Lee
13β-(β-D-Glucopyranosyloxy)kaur-16-en-18-oic acid β-D-glucopyranosyl ester
(4α)-13-(β-D-glucopyranosyloxy)kaur-16-en-18-oic acid β-D-glucopyranosyl ester
Kaur-16-en-18-oic acid, 13-(β-D-glucopyranosyloxy)-, β-D-glucopyranosyl ester, (4α)-
(4alpha)-13-(beta-D-Glucopyranosyloxy)kaur-16-en-18-oic acid beta-D-glucopyranosyl ester | [Molecular Formula]
C32H50O13 | [MDL Number]
MFCD06799426 | [MOL File]
64849-39-4.mol | [Molecular Weight]
642.73 |
| Chemical Properties | Back Directory | [Melting point ]
178～181℃ | [Boiling point ]
802.5±65.0 °C(Predicted) | [density ]
1.45 | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) | [form ]
neat | [pka]
12.51±0.70(Predicted) | [color ]
White to Off-White | [Optical Rotation]
[α]/D -37 to -47°, c =0.5 in methanol | [Stability:]
Hygroscopic | [Major Application]
food and beverages | [Cosmetics Ingredients Functions]
SKIN CONDITIONING
HUMECTANT | [InChIKey]
YWPVROCHNBYFTP-OSHKXICASA-N | [SMILES]
C[C@@]12CCC[C@](C)([C@H]1CC[C@]34CC(=C)[C@](CC[C@@H]23)(C4)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(=O)O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from sweet tea. | [Uses]
Rubusoside is used as a nutritive sweetener, derived from .Stevia rebaudiana Stevia glycosiede. | [Definition]
ChEBI: Rubusoside is a steviol glycoside that is steviol in which both the carboxy group and the tertiary allylic hydroxy group have been converted to their corresponding beta-D-glucosides. A precious bioactive natural sweetener which mainly exists the in Chinese sweet tea plant, Rubus suavissimus. It has a role as a sweetening agent and a plant metabolite. It is a beta-D-glucoside, a tetracyclic diterpenoid, a bridged compound and a steviol glycoside. It is functionally related to a steviol. | [Biological Activity]
Rubusoside is a natural next generation sugar substitute isolated from Rubus suavissimus S. Lee. Rubusoside exhibits antiangiogenic and antiallergic properties. It can be used as a solubilizing agent for assorted biologically active agents. | [Synthesis]
A method for extracting rubusoside (Sweet tea glycoside), comprising the steps of:
Using 5g of sweet tea powder through 60 mesh sieve, add 15ml 0.3% dodecyldimethyl betaine surfactant, cold immersion for 15min, then extracted with solid-liquid | [in vivo]
Rubusoside (50-300 mg/kg; po; single dose) exerts anti-inflammatory and antiasthmatic activities in an OVA-induced experimental allergic asthma mouse model. Moreover, Rubusoside inhibits OVA-induced activation of the NF-κB pathway in lung tissue[4].
| Animal Model: | Ovalbumin‐induced mice allergic asthma model[4] | | Dosage: | 50, 150, 300 mg/kg | | Administration: | po; mixed with PBS (phosphate-buffered saline, pH 7.4) 1 hr before OVA treatment (intraperitoneal injected with 20 μg OVA and intranasal spray 1% OVA solution from Day 21 to Day 23) | | Result: | Contributed to the decrease of inflammatory cytokines (TNF-α, IL-13, IL-6, IL-5, and IL-4) inside the BALF of mice with asthma.
Led a decline of OVA-dependent IgE and IgG1 inside the serum was also noticed in these mice.
Enhanced the mRNA level of Foxp3 inside the mice lung affected with asthma while decrease that of IL-17A, IL-23, and RORγt.
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