| Identification | Back Directory | [Name]
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol | [CAS]
65004-42-4 | [Synonyms]
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol
4(3H)-Pyrimidinone, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl- | [Molecular Formula]
C10H12N4O | [MDL Number]
MFCD00097142 | [MOL File]
65004-42-4.mol | [Molecular Weight]
204.23 |
| Hazard Information | Back Directory | [Uses]
Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM[1]. | [References]
[1] Montalbetti N, et al. Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochem Pharmacol. 2015 Aug 1;96(3):216-24. DOI:10.1016/j.bcp.2015.05.002 |
|
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|