| Identification | Back Directory | [Name]
Indeloxazine hydrochloride | [CAS]
65043-22-3 | [Synonyms]
Elen
Noin
CI 874
CI874l
CI-874l
YM 08054
YM 08054-1
Indeloxazine HCl
Indeloxazine hydrochloride
Indeloxadine hydrochloride
Indeloxazine hydrochloride USP/EP/BP
Indeloxazine Hydrochloride: Indeloxazine HCl
2-(3H-Inden-4-yloxymethyl)morpholine hydrochloride
MORPHOLINE, 2-[(1H-INDEN-7-YLOXY)METHYL]-, HYDROCHLORIDE
(±)-2-[(1H-Inden-7-yloxy)methyl]morpholine hydrochloride
Morpholine,2-[(1H-inden-7-yloxy)Methyl]-, hydrochloride (1:1) | [Molecular Formula]
C14H18ClNO2 | [MDL Number]
MFCD00875849 | [MOL File]
65043-22-3.mol | [Molecular Weight]
267.75 |
| Safety Data | Back Directory | [RIDADR ]
3249 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Toxicity]
LD50 in mice (mg/kg): 47 i.v. (Tachikawa) |
| Hazard Information | Back Directory | [Description]
Indeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia.
In animal models indeloxazine reportedly enhances brain energy metabolism and
monoamine content; its claimed protective effect on ischemia-induced amnesia is
supported by the prolonged step-through latency in passive avoidance tests. | [Chemical Properties]
Polymorphic Forms: Pale yellow needle-shaped crystals obtained from methanol, melting point 169-170°C; colorless acicular crystals obtained from acetone, melting point 155-156°C. Acute toxicity LD50 in mice (mg/kg): 47 mg/kg by intravenous injection. (+)-Form: Crystals obtained from ethanol, melting point 112-113°C. [α]D21 + 4.9° (C = 5, methanol). (-)-Form: Crystals obtained from isopropanol, melting point 142-142.5°C. [α]D20 - 4.9° (C = 5, methanol). | [Originator]
Yamanouchi (Japan) | [Uses]
Antidepressant. | [Brand name]
Elen | [Metabolic pathway]
After oral administration of indeloxazine hydrochloride
to rats, two conjugates, which are labile to a-
glucosidase hydrolysis but refractory to b-glucosidase,
are isolated from the urine and identified as a-D-
glucopyranosides of trans-4-(2-morpholinylmethoxy)-
1,2-indandiol and trans-6-[[(1,2-dihydroxy-4-
indanyl)oxy]-methyl]-3-morpholinone. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Candia Thamtech Company Limited
|
| Tel: |
0371-86615086 18203638366 0371-86159066 13526786601 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15771/0_EN.htm |
|