| Identification | Back Directory | [Name]
6-Phenanthridinamine, 8-(trifluoromethyl)- | [CAS]
651055-83-3 | [Synonyms]
6-Amino-8-trifluoromethylphenanthridine
6-Phenanthridinamine, 8-(trifluoromethyl)- | [Molecular Formula]
C14H9F3N2 | [MDL Number]
MFCD30294025 | [MOL File]
651055-83-3.mol | [Molecular Weight]
262.23 |
| Chemical Properties | Back Directory | [Melting point ]
146-149 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
404.9±40.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A solid | [pka]
5.99±0.40(Predicted) | [color ]
Beige |
| Hazard Information | Back Directory | [Description]
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine . It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM. 6A-8tFP directly competes with protein substrates for the ribosomal active site. | [Uses]
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site. | [storage]
Store at -20°C | [References]
[1] Bach, et al. Isolation of drugs active against mammalian prions using a yeast-based screening assay. Nat. Biotechnol. 21(9), 1075-1081 (2003). |
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