| Identification | Back Directory | [Name]
3-ethynylserine | [CAS]
65207-64-9 | [Synonyms]
3-ethynylserine
D-threo-Pent-4-ynonic acid, 2-amino-2,4,5-trideoxy- | [Molecular Formula]
C5H7NO3 | [MOL File]
65207-64-9.mol | [Molecular Weight]
129.11 |
| Hazard Information | Back Directory | [Uses]
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags,
respectively. | [Definition]
ChEBI: L-beta-ethynylserine is a non-proteinogenic L-alpha-amino acid that is L-propargylglycine which is carrying a hydroxy group at the 3R position. It has a role as an antimetabolite, an antibacterial agent, a bacterial metabolite and a fungal metabolite. It is a terminal acetylenic compound and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-propargylglycine. It is a tautomer of a L-beta-ethynylserine zwitterion. | [References]
[1] Ignacio BJ, Dijkstra J, Mora N, et al. THRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog. Nat Commun. 2023;14(1):3367. DOI:10.1038/s41467-023-39063-7 |
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