| Identification | Back Directory | [Name]
Cefetrizole | [CAS]
65307-12-2 | [Synonyms]
Cefetrizole
(6R,7R)-8-Oxo-7-[2-thienylacetylamino]-3-[(1H-s-triazol-3-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[[2-(2-thienyl)acetyl]amino]-3-[(1H-1,2,4-triazol-5-ylthio)methyl]-, (6R,7R)- | [Molecular Formula]
C16H15N5O4S3 | [MDL Number]
MFCD00864923 | [MOL File]
65307-12-2.mol | [Molecular Weight]
437.52 |
| Hazard Information | Back Directory | [Uses]
Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively. | [Biological Activity]
Ceftezole is an α-Glucosidase inhibitor with IC50 and Ki values of 2.1 μM and 0.578 μM, respectively. | [in vitro]
In in vitro α-Glucosidase assays, Ceftezole is shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a K i value of 5.78×10 -7 M when the enzyme mixture is pretreated with ceftezole. | [in vivo]
Using an in vivo streptozotocin-induced mouse model, blood glucose levels are confirmed to be decreased by 30% 20 min after Ceftezole treatment (10 mg/kg/day). Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA are also slightly decreased compare to controls following Ceftezole treatment[1]. | [target]
IC50: 2.1 μM (α-Glucosidase)
Ki: 0.578 μM (α-Glucosidase) | [References]
[1] Lee DS, et al. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. Int J Mol Med. 2007 Sep;20(3):379-83. PMID:17671744 |
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