| Identification | Back Directory | [Name]
Cloxacepride | [CAS]
65569-29-1 | [Synonyms]
Cloxacepride
5-Chloro-4-[(4-chlorophenoxy)acetylamino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
5-Chloro-4-[[(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)acetyl]amino]-N-[2-(diethylamino)ethyl]-2-methoxy- | [Molecular Formula]
C22H27Cl2N3O4 | [MDL Number]
MFCD00867084 | [MOL File]
65569-29-1.mol | [Molecular Weight]
468.37 |
| Hazard Information | Back Directory | [Uses]
Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity[1][2]. | [in vivo]
Oral ED50 values for cloxacepride of 46-49 mg/kg were comparable to that of theophylline (HY-B0809) and to an intravenous injection of 2 mg/kg of disodium chromoglycate (DSCG) followed by immediate challenge[1].
Cloxacepride has anti-PCA activity when administered orally 15 or 60 min before antigenic challenge[1]. | [References]
[1] Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70. DOI:10.1021/jm00361a022
[2] Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44. DOI:10.1016/0143-4160(87)90008-x
[3] Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):264-8. PMID:6201147 |
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