| Identification | Back Directory | [Name]
Catechin 7-o-beta-D-xyloside | [CAS]
65597-47-9 | [Synonyms]
C09617
Catechin 7-o-beta-D-xyloside
Catechin7-O-β-D-glucopyranoside
(2R,3S)-catechin 7-O-β-D-glucopyranoside | [Molecular Formula]
C20H22O10 | [MOL File]
65597-47-9.mol | [Molecular Weight]
422.383 |
| Hazard Information | Back Directory | [Uses]
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research[1][2][3]. | [Definition]
ChEBI: (+)-catechin 7-O-beta-D-xyloside is a monosaccharide derivative that is (+)-catechin substituted by a beta-D-xylopyranosyl moiety at position 7 via a glycosidic linkage. It is a beta-D-xyloside and a monosaccharide derivative. It is functionally related to a (+)-catechin. | [in vivo]
Catechin 7-O-β-D-glucopyranoside (intraperitoneal injection; 10 mg/kg; once) treatment shows mild protective effect against lethality induced by LPS/D-GalN[1].
Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis[2]. | Animal Model: | Mice injected with LPS/D-GalN[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; 10 mg/kg; once | | Result: | Showed 80% LPS/DGalN-induced lethality in mice. |
| Animal Model: | Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis [2] | | Dosage: | 10 mg/kg | | Administration: | Oral administration; 10 mg/kg; once daily; 7 days | | Result: | Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats.
Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats. |
| [References]
[1] Zheng MS, et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica. Arch Pharm Res. 2011 Sep;34(9):1443-50. DOI:10.1007/s12272-011-0905-6
[2] Kook SH, et al. Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. Int Immunopharmacol. 2015 Dec;29(2):521-527. DOI:10.1016/j.intimp.2015.10.003
[3] Kim KC, et al. Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells. Cell Biochem Funct. 2010 Dec 2;28(8):651-60. DOI:10.1002/cbf.1703 |
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