| Identification | Back Directory | [Name]
4-Methyltetrahydro-2H-pyran-4-carbaldehyde | [CAS]
65626-22-4 | [Synonyms]
4-Methyloxane-4-carbaldehyde
4-formyl-4-methyl-tetrahydropyran
4-Methyl-tetrahydro-pyran-4-carbaldehyde
4-Methyltetrahydro-2H-pyran-4-carbaldehyde
Tetrahydro-4-methyl-2H-pyran-4-carboxaldehyde
2h-pyran-4-carboxaldehyde, tetrahydro-4-methyl- | [Molecular Formula]
C7H12O2 | [MDL Number]
MFCD14582418 | [MOL File]
65626-22-4.mol | [Molecular Weight]
128.17 |
| Chemical Properties | Back Directory | [Boiling point ]
180.1±33.0 °C(Predicted) | [density ]
1.046±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-methyltetrahydro-2H-pyran-4-carbaldehyde from 4-(hydroxymethyl)-4-methyltetrahydropyran: To a 100 mL three-necked round-bottomed flask was added a solution of 4-(hydroxymethyl)-4-methyltetrahydropyran (compound 188.2, 300 mg, 2.30 mmol) in dichloromethane (15 mL). Subsequently, Dess-Martin reagent (1.17 g, 2.76 mmol) was added to the reaction system. The reaction mixture was stirred at room temperature for 2 hours before the reaction was quenched with 15 mL of water. The aqueous phase was extracted with 20 mL of dichloromethane and the organic layers were combined and dried over anhydrous sodium sulfate. Finally, 200 mg (68% yield) of the target product 4-methyltetrahydro-2H-pyran-4-carbaldehyde was obtained as a yellow oil by concentration under reduced pressure. | [References]
[1] Patent: EP1431285, 2004, A1. Location in patent: Page 107
[2] Patent: US2008/194577, 2008, A1. Location in patent: Page/Page column 26
[3] Patent: WO2005/58881, 2005, A1. Location in patent: Page/Page column 30-31
[4] Patent: WO2006/1752, 2006, A1. Location in patent: Page/Page column 92
[5] Patent: US2011/82138, 2011, A1. Location in patent: Page/Page column 26 |
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