| Identification | Back Directory | [Name]
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, 7-[(2-fluorophenyl)methyl]- | [CAS]
65829-22-3 | [Synonyms]
OYYF-175
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, 7-[(2-fluorophenyl)methyl]- | [Molecular Formula]
C17H14FN5 | [MOL File]
65829-22-3.mol | [Molecular Weight]
307.33 |
| Hazard Information | Back Directory | [Uses]
OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains[1]. | [References]
[1] Yue Li, et al. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur J Med Chem. 2022 Jan 15;228:113979. DOI:10.1016/j.ejmech.2021.113979 |
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