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65896-16-4

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65896-16-4 Structure

65896-16-4 Structure
IdentificationBack Directory
[Name]

Romifidine
[CAS]

65896-16-4
[Synonyms]

Romidys
St 2130
STH 2130
Romifidine
Romifidinum
Romifidine >
2-(2-Bromo-6-fluoroanilino)-2-imidazoline
2-(2-Bromo-6-fluorophenylamino)-2-imidazoline
N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-
[Molecular Formula]

C9H9BrFN3
[MDL Number]

MFCD00868606
[MOL File]

65896-16-4.mol
[Molecular Weight]

258.093
Chemical PropertiesBack Directory
[Melting point ]

110 °C
[Boiling point ]

303.2±52.0 °C(Predicted)
[density ]

1.72±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 250 mg/mL (968.65 mM; Need ultrasonic)
[form ]

powder to crystal
[pka]

8.69±0.50(Predicted)
[color ]

White to Light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
[HS Code ]

2933.29.2000
Hazard InformationBack Directory
[Uses]

Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].
[in vivo]

Romifidine (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies[1]. Romifidine (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses[2].

[storage]

Store at -20°C
[References]

[1] England GC, et al. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther. 1992 Jun;15(2):194-201. DOI:10.1111/j.1365-2885.1992.tb01007.x
[2] Hamm D, et al. Sedative and analgesic effects of detomidine and romifidine in horses. Vet Rec. 1995 Apr 1;136(13):324-7. DOI:10.1136/vr.136.13.324
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