| Chemical Properties | Back Directory | [Melting point ]
247-247.5 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
428.4±27.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
powder | [pka]
9.75±0.20(Predicted) | [color ]
off-white | [SMILES]
O/N=C(C1=C2N=CC=C1)/C3=C2C=CC=C3 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.
A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. | [Biological Activity]
Cell permeable: yes''Primary Target
PERK |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|