| Identification | Back Directory | [Name]
5,5-DIBROMOMELDRUM'S ACID; >98% | [CAS]
66131-14-4 | [Synonyms]
66131-14-4
Dibromomeldrum'sAcid
5,5-Dibromomoldrum's acid
5,5-DIBROMOMELDRUM'S ACID; >98%
5,5-dibromo-2,2-dimethyl-1,3-Dioxane-4,6-dione
5,5-Dibromomeldrum's Acid (=5,5-Dibromo-2,2-dimethyl-4,6-dioxy-1,3-dioxane)
5,5-DIBROMOMELDRUM''S ACID (=5,5-DIBROMO-2,2-DIMETHYL-4,6-DIOXO-1,3-DIOXANE) 98+%
5,5-Dibromo-2,2-dimethyl-4,6-dioxo-1,3-dioxane
Dibromomalonic Acid Cyclic Isopropylidine Ester
cycl-Isopropylidene Dibromomalonate | [Molecular Formula]
C6H6Br2O4 | [MDL Number]
MFCD00059808 | [MOL File]
66131-14-4.mol | [Molecular Weight]
301.92 |
| Chemical Properties | Back Directory | [Melting point ]
75°C | [Boiling point ]
382.3±42.0 °C(Predicted) | [density ]
2.052±0.06 g/cm3(Predicted) | [storage temp. ]
Freezer | [solubility ]
almost transparency in Methanol | [form ]
powder to crystal | [color ]
White to Almost white | [InChIKey]
HPBNIRVIOCWRDC-UHFFFAOYSA-N | [CAS DataBase Reference]
66131-14-4 |
| Questions And Answer | Back Directory | [Uses]
5,5-Dibromo-2,2-dimethyl-4,6-dione-1,3-dioxane, also known as dibromomaldomic acid, is a pharmaceutical intermediate that can be used to prepare the antifolic acid agent pemetrexed disodium. |
| Hazard Information | Back Directory | [Reactions]
Selective α-bromination of aldehydes and α′-bromination of α,β-unsaturated ketones; reductive coupling to an ethylenetetracarboxylate. | [Synthesis]
The preparative method of 5,5-Dibromo-2,2-dimethyl-1,3-dioxane-4,6-dione: by bromination of Meldrum's acid (2,2-Dimethyl-1,3-dioxane-4,6-dione) (commercially available) with Bromine in the presence of Potassium Hydroxide or Sodium Hydroxide eq 1).
| [References]
1. Bloch, R. S 1978, 140.
2. Davidson, D.; Bernhard, S. A. JACS 1948, 70, 3426.
3. Synder, H. R.; Kruse, C. W. JACS 1958, 80, 1942.
4. Novikov, V. L.; Shestak, O. P.; Kamernitskii, A. V.; Elyakov, G. B. Izv. Akad. Nauk SSSR, Ser. Khim. 1982, 476 (CA 1982, 96, 180 832).
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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