| Identification | Back Directory | [Name]
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine | [CAS]
662164-09-2 | [Synonyms]
D3-βArr
D3-ΒARR
C 00379308
D3- beta Arr
NCGC00379308
D3-βArr?- NCg
D3-βArr- NCGC 00379308
D3-betaArr >=98% (HPLC)
D3-βArr?- NCGC 00379308
4-Quinazolinamine, N-(1-phenylethyl)-2-(1-piperazinyl)-
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine | [Molecular Formula]
C20H23N5 | [MDL Number]
MFCD04077665 | [MOL File]
662164-09-2.mol | [Molecular Weight]
333.43 |
| Hazard Information | Back Directory | [Uses]
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1]. | [Biological Activity]
D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling th at initiates translocation of β-Arr 1 by direct TSHR activationwhile showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation. | [References]
[1] Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. DOI:10.1124/jpet.117.244095 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
| Company Name: |
InvivoChem
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13549236410 |
| Website: |
https://www.invivochem.cn/ |
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