| Identification | Back Directory | [Name]
NSC54180 | [CAS]
6623-35-4 | [Synonyms]
NSC54180
5-BroMo-2-hydroxy-4-Methyl-benzoic acid
Benzoic acid, 5-bromo-2-hydroxy-4-methyl- | [Molecular Formula]
C8H7BrO3 | [MDL Number]
MFCD11044841 | [MOL File]
6623-35-4.mol | [Molecular Weight]
231.04 |
| Chemical Properties | Back Directory | [Melting point ]
205-208 °C | [Boiling point ]
359.2±42.0 °C(Predicted) | [density ]
1.739±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
2.68±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
A) Synthesis of 5-bromo-2-hydroxy-4-methylbenzoic acid: 2-hydroxy-4-methylbenzoic acid (5.00 g) was dissolved in acetic acid (70.0 mL) and bromine (1.68 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 5.5 hours. Upon completion of the reaction, water was added to the mixture and the precipitate was collected by filtration. The precipitate was dried under reduced pressure to give the target compound 5-bromo-2-hydroxy-4-methylbenzoic acid (6.78 g). The result of mass spectrometry analysis: [M-H]? 229.0. | [References]
[1] Patent: WO2018/24224, 2018, A1. Location in patent: Page/Page column 80; 81
[2] Patent: US2018/127370, 2018, A1. Location in patent: Paragraph 0892
[3] Journal of the Chemical Society, 1914, vol. 105, p. 1891
[4] Journal fuer Praktische Chemie (Leipzig), 1915, vol. <2> 91, p. 388
[5] Patent: EP1391451, 2004, A1. Location in patent: Page 84 |
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