| Identification | Back Directory | [Name]
6-amino-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile | [CAS]
663214-48-0 | [Synonyms]
WAY-324168
6-amino-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile
8H-1,3-Dioxolo[4,5-g][1]benzopyran-7-carbonitrile, 6-amino-8-(3,4,5-trimethoxyphenyl)-
Inhibitor,cancer,antiproliferative,A375,Antiproliferative agent-13,Antiproliferative agent 13,WAY324168,inhibit,WAY 324168,microtubule inhibitor,Antiproliferative agent13 | [Molecular Formula]
C20H18N2O6 | [MDL Number]
MFCD04126993 | [MOL File]
663214-48-0.mol | [Molecular Weight]
382.37 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (130.76 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC50 value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer[1]. | [References]
[1] Zhang H, et al. Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities. Eur J Med Chem. 2018 Sep 5;157:380-396 DOI:10.1016/j.ejmech.2018.07.043 |
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