66508-53-0

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66508-53-0 Structure

Identification	Back Directory
[Name] Fosmidomycin
[CAS] 66508-53-0
[Synonyms] Antibiotic FR-31705 10 Mg, 50 Mg, 100 Mg, 1g Fosmidomycin sodium salt hydrate 3-(Formylhydroxyamino)propylphosphonic acid 3-Phosphono 1-(N-formylhydroxyamino)propane (3-(N-hydroxyforMaMido)propyl)phosphonic acid Phosphonic acid, P-[3-(formylhydroxyamino)propyl]- (3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt
[Molecular Formula] C4H10NO5P
[MDL Number] MFCD00865023
[MOL File] 66508-53-0.mol
[Molecular Weight] 183.1

Chemical Properties	Back Directory
[Melting point ] 158-160° (dec); mp 160-166° (dec) (Hemmi)
[storage temp. ] -20°C
[solubility ] H2O: soluble20mg/mL, clear
[form ] powder
[color ] white to beige
[Water Solubility ] H2O: 20mg/mL, clear

Safety Data	Back Directory
[WGK Germany ] 3
[Toxicity] LD50 in mice and rats (mg/kg): >11000 orally; ~8000 s.c. (Wiesner, 2003)

Hazard Information	Back Directory
[Uses] Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.
[Definition] ChEBI: Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme i the non-mevalonate pathway of isoprenoid biosynthesis.
[Biochem/physiol Actions] Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).

66508-53-0 suppliers list

Company Name:	Guangzhou Isun Pharmaceutical Co., Ltd
Tel:	020-39119399 18927568969
Website:	http://www.isunpharm.com

Company Name:	Biosynth Biological Technology (Suzhou) Co Ltd
Tel:	51288865780
Website:	www.biosynth.com

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