| Identification | Back Directory | [Name]
MSOP | [CAS]
66515-29-5 | [Synonyms]
MSOP
2-Methyl-O- phosphonoserine
Serine, 2-methyl-O-phosphono-
(RS)-α-Methylserine-O-phosphate
(R,S)-a-Methylserine-O-phosphate
(RS)-ALPHA-METHYLSERINE-O-PHOSPHATE | [Molecular Formula]
C4H10NO6P | [MDL Number]
MFCD00673768 | [MOL File]
66515-29-5.mol | [Molecular Weight]
199.1 |
| Chemical Properties | Back Directory | [Boiling point ]
454.0±55.0 °C(Predicted) | [density ]
1.681±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
H2O: soluble3mg/mL, clear (warmed) | [form ]
powder | [pka]
1.66±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
MSOP is a selective antagonist of group III mGlu receptors. | [Biological Activity]
Selective group III metabotropic glutamate receptor antagonist. Displays an apparent K D 爋f 51 μ M for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μ M for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Also available as part of the Group III mGlu Receptor Tocriset™ . | [in vivo]
It is found that TBOA-induced antinociceptive effects are significantly blocked by intrathecal co-administration of MSOP (second phase of formalin model: F3,16=30.96, P<0.001; CFA model: F3,16=30.77, P<0.001). As expected, intrathecal TBOA (10 μg) reduces the number of formalin-induced flinches and shakes by 47% of the value in the saline-treated group in the second phase (P<0.001) and blocked the CFA-induced decrease in ipsilateral paw withdrawal latency by 60% of the value in the saline-treated group (P=0.01). The number of formalin-induced flinches in the second phase in the group treated with MSOP and TBOA is increased by 56% (P=0.04) of the value in the TBOA-treated group. CFA-induced paw withdrawal latency in the group treated with MSOP and TBOA is decreased by 86% (P=0.03) of the value in the TBOA-treated group[2]. | [storage]
Store at RT |
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