| Identification | Back Directory | [Name]
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE | [CAS]
66684-61-5 | [Synonyms]
2,4-Difluoro-6-methoxynitrobenzene
1,5-Difluoro-3-Methoxy-2-nitro-benz
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
Benzene, 1,5-difluoro-3-Methoxy-2-nitro-
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE ISO 9001：2015 REACH
3,5-Difluoro-2-nitroanisole【1,5-Difluoro-3-methoxy-2-nitrobenzene】
1,5-Difluoro-3-methoxy-2-nitrobenzene, 3,5-Difluoro-2-nitrophenyl methyl ether | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C7H5F2NO3 | [MDL Number]
MFCD11865203 | [MOL File]
66684-61-5.mol | [Molecular Weight]
189.12 |
| Chemical Properties | Back Directory | [Boiling point ]
238℃ | [density ]
1.414 | [Fp ]
98℃ | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
1. 3,5-difluoroanisole (30 g, 208 mmol) was dissolved in 260 mL of dichloromethane at 0 °C. 2. Fuming nitric acid (60 mL) at a concentration of greater than 90% was added slowly and dropwise to the above solution. 3. The reaction mixture was kept stirred at 0 °C for 3 h. 4. After completion of the reaction, the reaction mixture was washed with water. 5. The aqueous phase was extracted with dichloromethane. 6. The organic phases were combined and washed with brine, followed by drying with magnesium sulfate.7. The dried organic phase was concentrated on a rotary evaporator.8. The residue was recrystallized by solvent mixing of hexane and ethyl acetate to afford 28.5 g (72% yield) of 1,5-difluoro-3-methoxy-2-nitrobenzene, the product being an off-white powder.1H NMR (400 MHz, DMSO) δ ppm: 7.20 (m, 2H), 3.91 (s, 3H). | [References]
[1] Patent: US2009/143367, 2009, A1. Location in patent: Page/Page column 30
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7621 - 7638 |
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