| Identification | Back Directory | [Name]
L-Leucine, N-L-tyrosyl-, mono(trifluoroacetate) (9CI) | [CAS]
66852-01-5 | [Synonyms]
Tyrosylleucine TFA
L-Leucine, N-L-tyrosyl-, mono(trifluoroacetate) (9CI) | [Molecular Formula]
C17H23F3N2O6 | [MOL File]
66852-01-5.mol | [Molecular Weight]
408.37 |
| Hazard Information | Back Directory | [Uses]
Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1]. | [in vivo]
Tyrosylleucine (Tyr-Leu, YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.)[2]. | [References]
[1] Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257. DOI:10.1038/s41598-020-59039-7
[2] Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604. DOI:10.1016/j.febslet.2009.12.008 |
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