| Identification | Back Directory | [Name]
2H-Pyran, tetrahydro-2-[(28-phenyl-3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl)oxy]- | [CAS]
669556-53-0 | [Synonyms]
2H-Pyran, tetrahydro-2-[(28-phenyl-3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl)oxy]- | [Molecular Formula]
C30H52O11 | [MDL Number]
MFCD34471244 | [MOL File]
669556-53-0.mol | [Molecular Weight]
588.73 |
| Hazard Information | Back Directory | [Uses]
Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
|