| Identification | Back Directory | [Name]
2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-6-{[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl}pyrimidin-4(3H)-one | [CAS]
669749-45-5 | [Synonyms]
DCE42
DCE-42
DCE 42
DCE_42
2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-6-{[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl}pyrimidin-4(3H)-one | [Molecular Formula]
C22H19N9O2S | [MOL File]
669749-45-5.mol | [Molecular Weight]
473.51 |
| Hazard Information | Back Directory | [Description]
DCE_42 is a novel EZH2 inhibitor that also displays significant anti-proliferation activity against lymphoma cell lines. | [Uses]
DCE_42 is a potent EZH2 inhibitor with an IC50 value of 22.6 μM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma[1]. | [IC 50]
EZH2: 22.6 μM (IC50) | [References]
[1] Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. DOI:10.1016/j.bmcl.2016.05.018 |
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