| Identification | Back Directory | [Name]
2',5'-DIDEOXYADENOSINE | [CAS]
6698-26-6 | [Synonyms]
NSC 95943
2',5'-DD-ADO
2',5'-DIDEOXYADENOSINE
Adenosine, 2',5'-dideoxy-
2',5'-Dideoxyadenosine >=95% (HPLC), solid
2,5-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem
5-(6-AMINOPURIN-9-YL)-2-METHYLTETRAHYDROFURAN-3-OL
(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-Methyltetrahydrofuran-3-ol
NSC 95943 2',5'-DIDEOXYADENOSINE
phosphoric acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl [hydroxy(phosphonooxy)phosphoryl] [(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] ester | [Molecular Formula]
C10H13N5O2 | [MDL Number]
MFCD00210904 | [MOL File]
6698-26-6.mol | [Molecular Weight]
235.24 |
| Chemical Properties | Back Directory | [Boiling point ]
547.0±60.0 °C(Predicted) | [density ]
1.77±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble
| [form ]
solid
| [pka]
14.06±0.60(Predicted) | [color ]
white
| [InChI]
InChI=1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1 | [InChIKey]
FFHPXOJTVQDVMO-DSYKOEDSSA-N | [SMILES]
C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)C[C@@H]1O |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC). | [Biochem/physiol Actions]
Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations. | [in vivo]
2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K+ and Cl- sparing effect of Fr EtOAc in rats[4].
| Animal Model: | Male Wistar rats (3-4 months old)[3] | | Dosage: | 0.1 mg/kg | | Administration: | IP; 15 min pre-treated | | Result: | Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats.
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