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67224-41-3

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67224-41-3 Structure

67224-41-3 Structure
IdentificationBack Directory
[Name]

ACTH (4-11)
[CAS]

67224-41-3
[Synonyms]

MEHFRWGK
ACTH (4-11)
ACTH (4-11), HUMAN
MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS
ADRENOCORTICOTROPIC HORMONE (4-11)
H-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-OH
ADRENOCORTICOTROPIC HORMONE (4-11), HUMAN
ADRENOCORTICOTROPIC HORMONE FRAGMENT 4-11
ACTH (4-11) (Adrenocorticotropic Hormone (4-11), human)
ACTH (4-11) (human, mouse, rat, porcine, bovine, ovine)
Methionyl-glutamyl-histidinyl-phenylalanyl-argininyl-tryptophanyl-glycinyl-lysine
L-Lysine, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-
N2-(N-(N-(N2-(N-(N-(N-L-Methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycyl)-L-lysine
ACTH (4-11) Met-Glu-His-Phe-Arg-Trp-Gly-Lys
[Molecular Formula]

C50H71N15O11S
[MDL Number]

MFCD00133035
[MOL File]

67224-41-3.mol
[Molecular Weight]

1090.26
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[solubility ]

Soluble in chloroform at 50mg/ml. Also soluble in dichloromethane, methanol or ethyl acetate
[form ]

Solid
[color ]

White to off-white
[Sequence]

Met-Glu-His-Phe-Arg-Trp-Gly-Lys
Hazard InformationBack Directory
[Description]

ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response. ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM. It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 μM. ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).
[Uses]

ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
[References]

[1] Hirobe T, et al. ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J Exp Zool. 2000 May 1;286(6):632-40. DOI:10.1002/(sici)1097-010x(20000501)286:63.0.co;2-4
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