| Identification | Back Directory | [Name]
TN ANTIGEN | [CAS]
67262-86-6 | [Synonyms]
TN EPITOPE
TN ANTIGEN
GALNAC-ALPHA1-O-SER
Ser(α-D-GalNHAc)-OH
GalNac-α-1-O-serine
N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE
N-Acetyl-α-D-galactosaMinyl-
1-O-serine
N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE
SERINYL 2-ACETAMIDO-2-DEOXY-A-GALACTOPYRANOSIDE
2-Acetamido-2-deoxy-a-D-galactopyranosyl serine
Serinyl 2-AcetaMido-2-deoxy-α-galactopyranoside
O-[2-(AcetylaMino)-2-deoxy-α-D-galactopyranosyl]-
O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine
L-Serine, O-[2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-
O-[2-(Acetylamino)-2-deoxy-alpha-D-galactopyranosyl]-L-serine
Serinyl 2-acetamido-2-deoxy-a-galactopyranoside, N-acetyl-a-D-galactosaminyl-1-O-serine
Serinyl 2-acetamido-2-deoxy-α-galactopyranoside, N-acetyl-α-D-galactosaminyl-1-O-serine | [Molecular Formula]
C11H20N2O8 | [MDL Number]
MFCD01863462 | [MOL File]
67262-86-6.mol | [Molecular Weight]
308.29 |
| Chemical Properties | Back Directory | [Melting point ]
198-201°C | [Boiling point ]
701.2±60.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Water | [form ]
Solid | [pka]
2.05±0.10(Predicted) | [color ]
Off-White to Yellow | [Stability:]
HYGROSCOPIC | [InChI]
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1 | [InChIKey]
REDMNGDGDYFZRE-WKWISIMFSA-N | [SMILES]
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
TN ANTIGEN is Yellow Solid
| [Uses]
A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines. | [Uses]
TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines
| [Definition]
ChEBI: O-(N-acetyl-alpha-D-galactosaminyl)-L-serine is a non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine. It has a role as a tumour antigen. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid. | [General Description]
Tn antigen?is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system. | [Biochem/physiol Actions]
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome. |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|