| Identification | Back Directory | [Name]
1,4-Dichloro-5,6,7,8-tetrahydrophthalazine | [CAS]
67279-24-7 | [Synonyms]
1,4-Dichloro-5,6,7,8-tetrahydrophthalazine
Phthalazine, 1,4-dichloro-5,6,7,8-tetrahydro- | [Molecular Formula]
C8H8Cl2N2 | [MDL Number]
MFCD02940890 | [MOL File]
67279-24-7.mol | [Molecular Weight]
203.07 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
1,4-Dichloro-5,6,7,8-tetrahydronaphthalene can be used in organic synthesis and pharmaceutical intermediates. | [Synthesis]
2,3,5,6,7,8-Hexahydrophthalazine-1,4-dione (40) (2.09 g, 12.6 mmol) was used as a starting material, which was suspended in phosphorus trichloride (POCl3, 10 mL) and heated to reflux for 1 hour. After completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water. The precipitated solid product was collected by filtration and dried in a vacuum oven to afford 1,4-dichloro-5,6,7,8-tetrahydro-2,3-diazanaphthalene (41) (2.23 g, 87% yield). The molecular ion peak (MH+) was determined as 203.0139 by high resolution mass spectrometry (HR MS). | [References]
[1] Patent: US2010/41663, 2010, A1. Location in patent: Page/Page column 42
[2] Patent: WO2008/110611, 2008, A1. Location in patent: Page/Page column 104
[3] Patent: WO2011/80510, 2011, A1. Location in patent: Page/Page column 71
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 707,708
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 14, p. 3642 - 3657 |
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| Company Name: |
SynAsst Chemical.
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021-60343070 |
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www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Cool Pharm, Ltd
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021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
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