| Identification | Back Directory | [Name]
FURIN INHIBITOR II | [CAS]
673202-67-0 | [Synonyms]
HEXA-D-ARGININE
H-(D)RRRRRR-NH2
FURIN INHIBITOR II
Hexa-D-arginine aMide
H-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-D-ARG-NH2 | [Molecular Formula]
C36H75N25O6 | [MDL Number]
MFCD04974168 | [MOL File]
673202-67-0.mol | [Molecular Weight]
954.14 |
| Chemical Properties | Back Directory | [density ]
1.59±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O : 50 mg/mL (52.40 mM; Need ultrasonic)DMSO : 5 mg/mL (5.24 mM; Need ultrasonic) | [form ]
lyophilized | [pka]
13.24±0.46(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
d(Arg-Arg-Arg-Arg-Arg-Arg)-NH2 |
| Hazard Information | Back Directory | [Uses]
Furin Inhibitor II has been used as a furin inhibitor:
- to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
- to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
- in furin cleavage assay.
| [General Description]
Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes. | [Biochem/physiol Actions]
Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein?4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases?and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1). | [in vivo]
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1]. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
Nextpeptide Inc
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+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
Ontores Biotech
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| Telephone: |
0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
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