67324-99-6

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67324-99-6 Structure

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[Name] 5-Iminodaunorubicin
[CAS] 67324-99-6
[Synonyms] 5-Iminodaunorubicin hydrochloride
[Molecular Formula] C27H31ClN2O9
[MOL File] 67324-99-6.mol
[Molecular Weight] 563

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[Uses] 5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].
[in vivo] In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic^[1].
[References] [1] R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9. PMID:6744318 [2] L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91. PMID:6896293

67324-99-6 suppliers list

Company Name:	Biosynth Biological Technology (Suzhou) Co Ltd
Tel:	51288865780
Website:	www.biosynth.com

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