| Identification | Back Directory | [Name]
6-CHLORO-2,3-DIAMINOTOLUENE | [CAS]
673487-36-0 | [Synonyms]
6-CHLORO-2,3-DIAMINOTOLUENE
4-Chloro-3-Methylbenzene-1,2-diaMine
1,2-Benzenediamine, 4-chloro-3-methyl- | [Molecular Formula]
C7H9ClN2 | [MDL Number]
MFCD09026957 | [MOL File]
673487-36-0.mol | [Molecular Weight]
156.61 |
| Chemical Properties | Back Directory | [Melting point ]
46-47 °C(Solv: benzene (71-43-2); ligroine (8032-32-4)) | [Boiling point ]
305.6±37.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [pka]
3.65±0.10(Predicted) | [Appearance]
Brown to reddish brown Solid |
| Hazard Information | Back Directory | [Uses]
6-Chloro-2,3-diaminotoluene is a white solid powder at room temperature and pressure, with significant alkalinity and strong nucleophilicity. Due to the presence of two amino units in the ortho position of the benzene ring, it can undergo condensation reactions with aldehydes to prepare corresponding benzimidazole derivatives. This reaction is widely used to prepare benzimidazole drugs and bioactive molecules. It is an intermediate in organic synthesis and medicinal chemistry, such as Nemonapride.
| [Synthesis]
A solution of 3-chloro-2-methyl-6-nitroaniline in a mixture of acetic acid and water was heated to 90 °C, to which iron powder was added. The resulting reaction mixture was further heated at 90 °C for 2 hours. At the end of the reaction the reaction mixtu |
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