| Identification | Back Directory | [Name]
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE | [CAS]
67469-57-2 | [Synonyms]
CS-1338
GBR 12921
GBR-12783
GBR127832HCl
GBR 12783 DIHYDROCHLORIDE
1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine
Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine
Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
1-[2-(diphenylMethoxy)ethyl]-4-(3-phenylprop-2-en-1-yl)piperazine dihydrochloride | [Molecular Formula]
C28H32N2O | [MDL Number]
MFCD12828854 | [MOL File]
67469-57-2.mol | [Molecular Weight]
412.57 |
| Chemical Properties | Back Directory | [Melting point ]
>200°C (dec.) | [Boiling point ]
551℃ | [density ]
1.085 | [Fp ]
148℃ | [storage temp. ]
Desiccate at -20°C | [solubility ]
Methanol (Slightly), Water (Slightly, Heated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
GBR 12783 is a very potent and selective inhibitor of dopamine uptake. | [Definition]
ChEBI: 1-[2-(diphenylmethyl)oxyethyl]-4-(3-phenylprop-2-enyl)piperazine is a diarylmethane. | [Biological Activity]
A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM). | [in vivo]
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. | Animal Model: | Male Sprague-Dawley rats (180-200 g)[1] | | Dosage: | 10 mg/kg | | Administration: |
Intraperitoneal injection; for 100 minutes | | Result: | For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
|
|
|
|