| Identification | Back Directory | [Name]
2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose | [CAS]
67561-97-1 | [Synonyms]
2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose
2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-α-D-glucofuranose
α-D-Glucopyranose, 2-(acetylamino)-2-deoxy-5-thio-, 1,3,4,6-tetraacetate | [Molecular Formula]
C16H23NO9S | [MDL Number]
MFCD31618059 | [MOL File]
67561-97-1.mol | [Molecular Weight]
405.42 |
| Hazard Information | Back Directory | [Uses]
Ac4-5SGlcNAc is a pro-inhibitor of carbohydrate-based glycosyltransferases (OGTs). Ac4-5SGlcNAc inhibits o-GlcN acylation and interferes with the effects of o-GlcN on neural induction of human embryonic stem cells (hESCs), and reduces the invasive phenotype of breast cancer cells. Ac4-5SGlcNAc also targets other carbohydrate-processing enzymes[1]. | [References]
[1] Barkovskaya A, et al. Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Sci Rep. 2020 Oct 12;10(1):16992. DOI:10.1038/s41598-020-74083-z
[2] Andres LM, et al. Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation. ACS Chem Biol. 2017 Aug 18;12(8):2030-2039. DOI:10.1021/acschembio.7b00232 |
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