| Identification | Back Directory | [Name]
2-Thiophenecarboxylic acid, 3-[[2-(2-thienyl)acetyl]amino]-, methyl ester | [CAS]
676594-38-0 | [Synonyms]
JNK-IN-11
2-Thiophenecarboxylic acid, 3-[[2-(2-thienyl)acetyl]amino]-, methyl ester | [Molecular Formula]
C12H11NO3S2 | [MOL File]
676594-38-0.mol | [Molecular Weight]
281.35 |
| Chemical Properties | Back Directory | [Boiling point ]
510.5±50.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.59±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
JNK-IN-11 (compound 1) is a potent JNK inhibitor with an IC50 value of 2.2, 21.4, 1.8 μM for JNK1, JNK2, JNK3, respectively. JNK-IN-11 has the potential for the research of alzheimer and parkinson disease[1]. | [Definition]
ChEBI: Methyl 3-[2-(2-thienyl)acetamido]thiophene-2-carboxylate is a carboxamide resulting from the formal condensation of the carboxy group of 2-thienylacetic acid with the amino group of methyl 3-aminothiophene-2-carboxylate. It is a selective inhibitor of c-Jun N-terminal kinases (JNKs). It has a role as a c-Jun N-terminal kinase inhibitor. It is a methyl ester, a member of thiophenes and a secondary carboxamide. It is functionally related to a 2-thienylacetic acid. | [IC 50]
JNK1: 1.8 μM (IC50); JNK3: 2.2 μM (IC50); JNK2: 21.4 μM (IC50) | [References]
[1] Hom RK, et al. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7. DOI:10.1016/j.bmcl.2010.10.066 |
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