| Identification | Back Directory | [Name]
8-BROMOQUINOLIN-2(1H)-ONE | [CAS]
67805-67-8 | [Synonyms]
8-bromoquinolin-2-ol
8-BROMOQUINOLIN-2(1H)-ONE
8-Bromo-1H-quinolin-2-one
8-BroMoquinoline-2(1h)-one
8-Bromo-2-hydroxyquinoline
2(1H)-Quinolinone, 8-bromo-
8-Bromoquinolin-2(1H)-one98%
8-Bromoquinolin-2(1H)-one 98%
8-Bromo-1,2-dihydroquinolin-2-one
8-Bromo-1,2-dihydro-2-oxoquinoline | [Molecular Formula]
C9H6BrNO | [MDL Number]
MFCD08741409 | [MOL File]
67805-67-8.mol | [Molecular Weight]
224.05 |
| Chemical Properties | Back Directory | [Melting point ]
196-198 °C | [Boiling point ]
390.2±42.0 °C(Predicted) | [density ]
1.620±0.06 g/cm3(Predicted) | [storage temp. ]
Room temperature. | [form ]
Peachy beige fine crystalline needles | [pka]
10.70±0.70(Predicted) | [Appearance]
Light yellow to light brown Solid | [InChI]
InChI=1S/C9H6BrNO/c10-7-3-1-2-6-4-5-8(12)11-9(6)7/h1-5H,(H,11,12) | [InChIKey]
HGJBIJWBYATVQY-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2Br)C=CC1=O |
| Hazard Information | Back Directory | [Uses]
8-Bromoquinolin-2(1H)-one is an organic compound that inhibits the production of inflammatory substances in the body. It is a long-chain alkene and a synthetic substance that is used to prepare pharmaceuticals. | [Application]
8-Bromoquinolin-2(1H)-one has been shown to have anti-cancer properties, as well as an inhibitory effect on inflammation. The drug is synthesized by reacting benzonitrile with bromine and ammonia in a reaction system. 8-Bromoquinolin-2(1H)-one inhibits the synthesis of prostaglandin E2 (PGE2) by inhibiting cyclooxygenase and lipoxygenase enzymes. It also binds with high affinity to the enzyme phospholipase A 2 (PLA 2 ), which results in a rapid hydrolysis of phospholipids and production of arachidonic acid, which leads to increased levels of PGE2. |
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