| Identification | Back Directory | [Name]
NORVERAPAMIL HYDROCHLORIDE | [CAS]
67812-42-4 | [Synonyms]
NORVERAPAMIL HCL
NORVERAPAMIL HYDROCHLORIDE
n-nor-(±)-verapamil hydrochloride
(±)-Norverapamill hydrochloride solution
(+/-)-VERAPAMIL, NOR-METHYL-, HYDROCHLORIDE
NorverapaMil HCl (N-DesMethyl VerapaMil HCl)
(+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH
a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- benzeneacetonitril
a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile | [Molecular Formula]
C26H37ClN2O4 | [MDL Number]
MFCD00078605 | [MOL File]
67812-42-4.mol | [Molecular Weight]
477.04 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Crystalline Solid | [Melting point ]
softens at 50°C, 155-160°C dec. | [Fp ]
9℃ | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
H2O: >10 mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
H2O: 15mg/mL, clear | [Stability:]
Hygroscopic | [InChI]
1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H | [InChIKey]
OEAFTRIDBHSJDC-UHFFFAOYSA-N | [SMILES]
CC(C)C(CCCNCCC1=CC=C(OC)C(OC)=C1)(C#N)C2=CC(OC)=C(OC)C=C2.Cl | [EPA Substance Registry System]
Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, hydrochloride (1:1) (67812-42-4) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Crystalline Solid | [Uses]
A metabolite of Verapamil | [General Description]
Norverapamil is a primary urinary metabolite of verapamil, a calcium channel blocker used in the treatment of hypertension, angina pectoris, and cardiac arrhythmia. Verapamil is also an effective preventive medication for migraines. This Certified Reference Material is applicable for use as starting material in calibrators or controls for verapamil testing methods by LC-MS/MS or GC-MS. | [Biochem/physiol Actions]
Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity. |
| Safety Data | Back Directory | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Acesys Pharmatech
|
| Telephone: |
18860950986 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15849/0_EN.htm |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|