| Identification | Back Directory | [Name]
1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE | [CAS]
679840-30-3 | [Synonyms]
RARECHEM AL BP 0325
2-(5-Bromo-2-fluorophenyl)-1,3-dioxolane
1,3-Dioxolane, 2-(5-bromo-2-fluorophenyl)-
1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE | [Molecular Formula]
C9H8BrFO2 | [MDL Number]
MFCD06209165 | [MOL File]
679840-30-3.mol | [Molecular Weight]
247.06 |
| Chemical Properties | Back Directory | [Boiling point ]
260.0±40.0 °C(Predicted) | [density ]
1.590±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
solid | [InChI]
1S/C9H8BrFO2/c10-6-1-2-8(11)7(5-6)9-12-3-4-13-9/h1-2,5,9H,3-4H2 | [InChIKey]
WWJNPWYIXIIEJG-UHFFFAOYSA-N | [SMILES]
FC1=CC=C(C=C1C2OCCO2)Br |
| Questions And Answer | Back Directory | [Uses]
1,1-Diethoxyethylene can be used as a pharmaceutical synthesis intermediate, such as in the preparation of the compound (3-[1,3]dioxolane-2-yl-4-fluoro-phenyl)-(8-nitro-quinoline-7-yl)-methanol. The specific steps are as follows: Magnesium (983 mg, 40.5 mmol) is suspended in anhydrous THF (30 ml). 1,2-Dibromoethane (0.17 ml, 2.02 mmol) is added, and the solution is stirred at room temperature for 20 minutes. 1,1-Diethoxyethylene (3.2 g, 1.295 mmol) is added dropwise, and the mixture is heated at 40 °C for 2 hours. After cooling to room temperature, Grignard reagent (0.43 M; 28.6 ml) is added at 0 °C to the anhydrous THF (30 ml) suspension of 8-nitroquinoline-7-carboxaldehyde 204 (2.5 g, 1.28 mmol). | [Application]
1,1-Diethoxyethylene can be used as a pharmaceutical synthesis intermediate. |
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Cochemical Ltd.
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029-86115547 17791676824 |
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http://www.cochemical.com |
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Grader reagent
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18221735425 |
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www.shxinping.net |
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