| Identification | Back Directory | [Name]
A-800141
(A800141) | [CAS]
681245-85-2 | [Synonyms]
A-800141
A-800141
(A800141)
(Z)-2-(2-(3-(diethylamino)prop-1-en-1-yl)phenylsulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
1-Naphthalenecarboxylic acid, 2-[[[2-[(1Z)-3-(diethylamino)-1-propen-1-yl]phenyl]sulfonyl]amino]-5,6,7,8-tetrahydro- | [Molecular Formula]
C24H30N2O4S | [MOL File]
681245-85-2.mol | [Molecular Weight]
442.57 |
| Hazard Information | Back Directory | [Uses]
A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM. A-800141 has weak inhibitory activity for MetAP1 (IC50 : 36 μM). GAPDH can be used as a biomarker to monitor the MetAP2 inhibition of A-800141. A-800141 has antiangiogenic and anticancer activity in a variety of xenograft tumor models[1]. | [References]
[1] Wang J, et al. Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1838-43. DOI:10.1073/pnas.0708766105 |
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| Company Name: |
DKMbiochem.Co. Ltd
|
| Telephone: |
15901859516 |
| Website: |
http://www.dkmbiochem.com/ |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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