| Identification | Back Directory | [Name]
beta-Cyclodextrin hydrate | [CAS]
68168-23-0 | [Synonyms]
CD
CYCLOHEPTAAMYLOSE
Cyclodextrin,Hydrate
schardinger á-dextrin
á-cyclodextrin hydrate
B-CYCLODEXTRIN HYDRATE
b-Cyclodextrin standard
SS-CYCLODEXTRIN HYDRATE
BETA-SHARDINGER DEXTRIN
BETA-SCHARDINGER DEXTRIN
BETA-CYCLODEXTRIN HYDRATE
CYCLOHEPTAAMYLOSE HYDRATE
beta-Cyclodextrin hydrate 99%
beta-Cyclodextrin hydrate,99%
Schardinger β-Dextrin hydrate
β-Schardinger dextrin, Cycloheptaamylose, Schardinger β-Dextrin hydrate
β-Cyclodextrin hydrate,β-Schardinger dextrin, Cycloheptaamylose, Schardinger β-Dextrin hydrate | [EINECS(EC#)]
231-493-2 | [Molecular Formula]
C42H70O35 | [MDL Number]
MFCD00150811 | [MOL File]
68168-23-0.mol | [Molecular Weight]
1134.98 |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
>260 °C (dec.)(lit.)
| [alpha ]
161 º (c=1, H2O 25 ºC) | [storage temp. ]
Refrigerator | [solubility ]
Water (Slightly) | [form ]
Crystalline Powder | [color ]
White | [Optical Rotation]
[α]20/D +142°, c = 1 in H2O (Dry basis) | [Water Solubility ]
18.5 g/L (25 ºC) | [Merck ]
14,2718 | [BRN ]
5915513 | [InChIKey]
WHGYBXFWUBPSRW-JXMPPWEANA-N |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Description]
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.1,2 The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.1,3 | [Uses]
beta-Cyclodextrin hydrate forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins. It is used in pharmaceutical research, as pharmaceutical intermediates and also as chemical reagents. | [General Description]
β-cyclodextrin (β-CD), a well-known macrocyclic oligosaccharide member of the CD family, is composed of seven D-glucose units connected via α(1→4) glycosidic bonds. Its ability to form several inclusion complexes with organic as well as inorganic compounds makes it a potential candidate in solid and solution state determinations. | [Purification Methods]
Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.] | [References]
[1] HOFFMAN T. Book Review: The Nicholas Effect: A Boy’s Gift to the World[J]. Journal of transplant coordination?: official publication of the North American Transplant Coordinators Organization (NATCO), 1999, 9 1: 281-281. DOI: 10.1177/090591999900900414
[2] G B WILLIAMSON J D W. Bacterial degradation of juglone?: Evidence against allelopathy?[J]. Journal of Chemical Ecology, 1990, 16 5: 1739-1742. DOI: 10.1007/bf01014105
[3] VENKATRAMANA M. RAO . Co-solubilization of poorly soluble drugs by micellization and complexation[J]. International Journal of Pharmaceutics, 2006, 319 1: Pages 98-106. DOI: 10.1016/j.ijpharm.2006.03.042 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | [Safety Statements ]
24/25 | [WGK Germany ]
2
| [RTECS ]
GU2293000
| [TSCA ]
Yes | [HS Code ]
35051000 | [Storage Class]
11 - Combustible Solids |
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