| Identification | Back Directory | [Name]
3-NITRO-2-PYRIDINESULFENYL CHLORIDE | [CAS]
68206-45-1 | [Synonyms]
NPYS-CL
OxytocinImpurity16
3-nitro-2-pyridinesulfenyl
2-(chlorosulfanyl)-3-nitropyridine
3-NITRO-2-PYRIDINESULFENYL CHLORIDE
3-Nitropyridin-2-yl hypochlorothioite
2-Pyridinesulfenyl chloride, 3-nitro-
(3-nitropyridin-2-yl)sulfanyl]chlorane
(3-nitropyridin-2-yl) thiohypochlorite
3-Nitro-2-pyridinesulfenyl chloride 95%
thiohypochlorous acid (3-nitro-2-pyridinyl) ester | [Molecular Formula]
C5H3ClN2O2S | [MDL Number]
MFCD00274609 | [MOL File]
68206-45-1.mol | [Molecular Weight]
190.61 |
| Chemical Properties | Back Directory | [Melting point ]
205 °C (dec.) (lit.) | [Boiling point ]
376.8±27.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
dichloromethane: soluble(lit.) | [pka]
-3.72±0.29(Predicted) |
| Hazard Information | Back Directory | [Uses]
3-Nitro-2-pyridinesulfenyl chloride (NpysCl) was employed as the starting material for the synthesis of N-, O- and S-Npys-protected amino acid. | [Preparation]
3-Nitro-2-pyridinesulfenyl chloride may be prepared by chlorination of bis(3-nitro-2-pyridyl) disulfide with gaseous chlorine. | [General Description]
The 3-nitro-2-pyridinesulphenyl (Npys) moiety is useful as a protecting-activating group for cysteine, particularly in the synthesis of cyclic and unsymmetrical disulfides. The stability of NpysCl was studied in various solvents. | [storage]
moisture sensitive, but stable for several weeks at rt under dry conditions; no decomposition is seen after 6 months in a refrigerator. | [Purification Methods]
The chloride crystallises as yellow needles from CH2Cl2. When pure, it is stable for several weeks at room temperature, and no decomposition was observed after 6 months at <0o. It is moisture sensitive. UV (MeCN) has at 231nm max ( 12,988), 264nm ( 5,784) and 372nm ( 3,117). [NMR and UV: Matsuda & Aiba Chem Lett 951 1978, Wagner et al. Chem Ber 75 935 1942.] |
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Energy Chemical
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Sigma-Aldrich
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Merck KGaA
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