| Identification | Back Directory | [Name]
2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE | [CAS]
68236-20-4 | [Synonyms]
AKOS NCG-0061
AKOS BBS-00006540
2-CHLORO-7-METHOXY-3-QUINOLINECARBALDEHYDE
2-Chloro-7-methoxyquinoline-2-carbaldehyde
2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE
2-Chloro-7-methoxyquinoline-3-carboxaldehyde
3-Quinolinecarboxaldehyde,2-chloro-7-methoxy-
2-chloro-7-methoxy-1H-quinoline-2-carboxaldehyde
2-Chloro-3-formyl-7-methoxyquinoline, 2-Chloro-3-formyl-7-methoxy-1-azanaphthalene | [Molecular Formula]
C11H8ClNO2 | [MDL Number]
MFCD02227048 | [MOL File]
68236-20-4.mol | [Molecular Weight]
221.64 |
| Questions And Answer | Back Directory | [Preparation]
The preparation of 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE is as follows: N-p-tolylacetamide (2b) (0.05 mol) was dissolved in 9.6 mL of dimethylformamide (0.125 mol), and 32 mL of phosphorus oxychloride (0.35 mol) was gradually added to the solution at 0 °C. The reaction mixture was placed in a round-bottom flask (RBF) equipped with a reflux condenser and a drying tube, and heated in an oil bath at 75-80 °C for 4-16 hours. The solution was then cooled to room temperature and subsequently poured into 100 mL of ice water. The precipitate was collected by filtration and recrystallized from ethyl acetate to give 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE, yield 75%; MP 122-123℃ (literature 123℃); FT-IR (ATR) ⁻¹ (cm⁻¹): 3051 (aromatic CH), 2873 (aldehyde CH), 1686 (C=O), 1576 (C=N), 1055 (C-Cl); ¹H NMR (400 MHz, chloroform-d): ⁻¹ 0.55 (s, 1H), 8.66 (s, 1H), 7.96 (d, J = 8.5 Hz, 1H), 7.79-7.63 (m, 2H), 2.57 (s, 3H); MS-API: [M+H] + 206.02 (calculated 205.03). | [Application]
2-Chloro-7-methoxy-3-quinoline carbaldehyde can be used as a pharmaceutical synthesis intermediate. |
| Chemical Properties | Back Directory | [Melting point ]
196-198°C | [Boiling point ]
373.9±37.0 °C(Predicted) | [density ]
1.348±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [pka]
-1.00±0.50(Predicted) |
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| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
AOKBIO Inc.
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021-68712331 3286104197 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19166/0_EN.htm |
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