| Identification | Back Directory | [Name]
4-(acetylamino)phenyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate | [CAS]
68483-33-0 | [Synonyms]
apyramide
4-(acetylamino)phenyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
1-(4-Chlorobenzoyl)-2-methyl-5-methoxy-1H-indole-3-acetic acid 4-(acetylamino)phenyl ester
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(acetylamino)phenyl ester
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(acetylamino)phenyl ester | [EINECS(EC#)]
270-913-9 | [Molecular Formula]
C27H23ClN2O5 | [MOL File]
68483-33-0.mol | [Molecular Weight]
490.93 |
| Chemical Properties | Back Directory | [Melting point ]
145-150 °C(Solv: benzene (71-43-2); methanol (67-56-1)) | [Boiling point ]
671.1±55.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.20±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Apyramide is an anti-inflammatory agent (NSAID) and behaves as a proagent of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2. | [in vivo]
Apyramide is far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibits anti-inflammatory activity on carrageenin-induced paw oedema, cotton pellet granuloma and adjuvant arthritis, as well as analgesic and antipyretic activities[1]. | [References]
[1] Sauvaire D, et al. Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents. Drugs Exp Clin Res. 1987;13(5):247-52. PMID:3500027
[2] M Cociglio, et al. Pharmacokinetics of an indomethacin pro-drug: apyramide after intravenous administration in dog. Eur J Drug Metab Pharmacokinet. Oct-Dec 1991;16(4):275-80. DOI:10.1007/BF03189972 |
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