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685514-01-6

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685514-01-6 Structure

685514-01-6 Structure
IdentificationBack Directory
[Name]

1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
[CAS]

685514-01-6
[Synonyms]

1-triisopropylsilylpyrrolo[2,3-b]pyridin-5-ol
1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol
1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol
1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol
1-[Tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol
1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-sulfonic acid
[Molecular Formula]

C16H26N2OSi
[MDL Number]

MFCD11616408
[MOL File]

685514-01-6.mol
[Molecular Weight]

290.48
Chemical PropertiesBack Directory
[Boiling point ]

341.6±35.0 °C(Predicted)
[density ]

1.03±0.1 g/cm3(Predicted)
[storage temp. ]

Store at 0-8 °C
[pka]

8.50±0.40(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Synthesis]

Add 10.8g (34mmol) of (1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 120mL of tetrahydrofuran to a round bottom flask equipped with a magnetic stirrer, an inert gas source and a separating funnel, and stir to dissolve; Add 34mL of 1mol/L sodium hydroxide solution and 4.60g (40.6mmol) of 30% hydrogen peroxide dropwise at 0°C. After the addition, React at 0°C for 1 hour and detect the reaction by TLC. Add 4.8g (20.24mmol) of sodium thiosulfate, adjust to pH=5 with 2mol/L hydrochloric acid, extract with ethyl acetate (2x200mL), combine the organic phases, wash with saturated brine in turn, dry with a sodium sulfate, and reduce Concentrate under pressure. The residue was purified by silica gel column chromatography [eluent: dichloromethane] to obtain 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 9.4g, yield 95.0%.
1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
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