| Identification | Back Directory | [Name]
2-(3-trifluoromethylphenyl)propionic acid | [CAS]
68718-08-1 | [Synonyms]
2-(3-Trifluoromethylphenyl)propanoic acid
2-(3-trifluoromethylphenyl)propionic acid
α-Methyl-3-(trifluoromethyl)-benzeneacetic Acid
Benzeneacetic acid, α-methyl-3-(trifluoromethyl)- | [Molecular Formula]
C10H9F3O2 | [MDL Number]
MFCD11036891 | [MOL File]
68718-08-1.mol | [Molecular Weight]
218.17 |
| Hazard Information | Back Directory | [Synthesis]
A solution of 3-(trifluoromethyl)phenylacetic acid (ALDRICH, 300 mg, 1 .470 mmol) in THF (2 mL) was added dropwise to a solution of lithium diisopropylamide, 2M solution in heptane/THF/ethylbenzene (ALDRICH, 2.94 mL, 5.88 mmol) in THF (5 mL) at -78 °C. After 1 h at -78 °C, methyl iodide (ALDRICH, 0.735 mL, 1 1.76 mmol) was added, and the solution was stirred for 1 hour. The mixture was hydrolyzed with 2N HCI until acidic pH was reached, extracted with DCM, dried over MgS04, filtered, and dried under vacuum to produce a crude. It was purified by flash column chromatography using hexane/EtOAc 85/15 to 0/100 to give 2-(3-trifluoromethylphenyl)propionic acid (304 mg, 1.39 mmol, 95% yield).
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