| Identification | Back Directory | [Name]
3-Isoxazolecarboxamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-(4-fluorophenyl)- | [CAS]
688050-42-2 | [Synonyms]
WAY-328158
N-(3-Carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-(4-fluorophenyl)isoxazole-3-carboxamide
3-Isoxazolecarboxamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-(4-fluorophenyl)- | [Molecular Formula]
C19H16FN3O3S | [MOL File]
688050-42-2.mol | [Molecular Weight]
385.41 |
| Chemical Properties | Back Directory | [Boiling point ]
506.5±50.0 °C(Predicted) | [density ]
1.433±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.55±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BCR-ABL-IN-7 (compound 4) is a WT and T315I mutant ABL kinases inhibitor. BCR-ABL-IN-7 effectively inhibits activities of WT and T315I mutant ABL kinases. BCR-ABL-IN-7 can be used for the research of chronic myeloid leukemia (CML) research[1]. | [References]
[1] Cao R, et al. Discovery of 2-Acylaminothiophene-3-Carboxamides as Multitarget Inhibitors for BCR-ABL Kinase and Microtubules. J Chem Inf Model. 2015 Nov 23;55(11):2435-42. DOI:10.1021/acs.jcim.5b00540 |
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