| Identification | Back Directory | [Name]
CAY10464 | [CAS]
688348-37-0 | [Synonyms]
CAY10464
CAY10464 Exclusive
1,3-dichloro-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
Benzene, 1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]- | [Molecular Formula]
C15H12Cl2O | [MDL Number]
MFCD08457907 | [MOL File]
688348-37-0.mol | [Molecular Weight]
279.16 |
| Chemical Properties | Back Directory | [Boiling point ]
409.3±45.0 °C(Predicted) | [density ]
1.265±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:1): .5 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar. CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations. It is inactive as an estrogen receptor ligands even at 100 μM. | [Uses]
CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM[1]. | [References]
[1] Philippe de Medina, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. DOI:10.1021/jm0498194
[2] Emad Naem,et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. DOI:10.1016/j.lfs.2012.06.002 |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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