| Identification | Back Directory | [Name]
Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2 | [CAS]
689284-12-6 | [Synonyms]
TAPI-2 acetate salt
Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2
N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide
N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
L-Alaninamide, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)- | [Molecular Formula]
C19H37N5O5 | [MDL Number]
MFCD22581509 | [MOL File]
689284-12-6.mol | [Molecular Weight]
415.53 |
| Hazard Information | Back Directory | [Uses]
TAPI 2 is a matrix metalloprotease (MMP) inhibitor, which inhibits merpin α and β homo-oligomers. | [Biochem/physiol Actions]
TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001. | [storage]
Store at -20°C |
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Enzo Biochem Inc
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